Gerald Joyce of the Scripps Research Institute in La Jolla, California, frets that as the boundaries blur, biologists are now going to be directing evolution and that we are witnessing “the end of Darwinism.” “Life on Earth,” Joyce has noted, “has demonstrated extraordinary resiliency and inventiveness in adapting to highly disparate niches. Perhaps the most significant invention of life is a genetic system that has an extensible capacity for inventiveness, something that likely will not be achieved soon for synthetic biological systems. However, once informational macromolecules are given the opportunity to inherit profitable variation through self-sustained Darwinian evolution, they just may take on a life of their own.”
This is not hyperbole. All the key barriers to the artificial synthesis of viruses and bacteria have been overcome, at least on a proof-of-principle basis. In 2002, researchers at SUNY Stony Brook made a living polio virus, constructed from its genetic code. Three years later, scientists worried about pandemic influenza decided to re-create the devastating 1918 Spanish flu virus for research purposes, identifying key elements of the viral genes that gave that virus the ability to kill at least 50 million people in less than two years. What all this means is that the dual-use dilemma that first hit chemistry a century ago, and then hit physics a generation later, is now emerging with special force in contemporary biology.